Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-analysis of 26 Randomized Controlled Trials

PurposeTo compare the effectiveness and safety of platelet-rich plasma (PRP) hyaluronic acid (HA) in patients with adult knee osteoarthritis (KOA) to explore most effective safe protocol by using a meta-analysis method.MethodsThis study was based on Cochrane methodology for conducting meta-analysis. Only randomized controlled trials an experimental group that used PRP control received HA were eligible this study. The participants adults who had KOA. outcome measures Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS), EuroQol VAS, International Knee Documentation Committee, Tegner score, Lequesne Scale, injury Outcome Score, satisfaction rate, adverse events. Subgroup analyses performed different doses, types, times interventions grades OA. Review Manager Database analyze included studies.ResultsTwenty-six involving 2430 included. WOMAC total scores, physical function VAS scores better than those at 3, 6, 12 months. pain, stiffness, Committee 6 There no significant difference events between 2 groups (relative risk 1.21, 95% confidence interval 0.95-1.54; P = .13).ConclusionsFor nonsurgical treatment KOA, compared HA, intra-articular injection could significantly reduce patients’ early pain improve function. groups. more these options comparable.Level EvidenceLevel I, Level I RCTs. To method. This studies. Twenty-six .13). For comparable.